5-FU + Cisplatin + Vinblastine + RT + Surgery

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Indication

Neoadjuvant chemoradiation +/- surgery for resectable cancer

  • 5-FU 300 mg/m2/d civi d1-21
  • Cisplatin 20mg/m2/d civi d1-5 and 17-21
  • Vinblastine 1 mg/m2/d iv bolus d1-4 and 17-20
  • Concurrent radiotherapy 45 Gy
  • Surgery

References

Urba SG et al. Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 2001; 19:305