5-FU + LV + Irinotecan

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Indication

Chemotherapy for locally advanced unresectable and metastatic cancer

Regimen 1

  • Irinotecan (CPT-11) 180 mg/m2 iv d1
  • Leucovorin 200 mg/m2 iv over 2 hrs d1 and 2
  • 5-FU 400 mg/m2 iv bolus followed by 600 mg/m2 civi over 22 hrs d1 and 2
  • Q2w

References

Bouche, O et al. Randomized multicenter phase II trial of a biweekly regimen of fluorouracil and leucovorin (LV5FU2), LV5FU2 plus cisplatin, or LV5FU2 plus irinotecan in patients with previously untreated metastatic gastric cancer: a Federation Francophone de Cancerologie Digestive Group Study--FFCD 9803. J Clin Oncol 2004; 22:4319

Regimen 2

  • Irinotecan (CPT-11) 80 mg/m2 iv over 30 min d1
  • Leucovorin 500 mg/m2 iv over 2 hrs d1
  • 5-FU 2000 mg/m2 iv over 22 hrs d1
  • Qw x 6 wks every 7 wks

References

Dank M et al. Randomized phase 3 trial of irinotecan (CPT11) + 5FU/folinic acid (FA) versus CDDP + 5-FU in 1st-line advanced gastric cancer patients. 2005 ASCO Annual Meeting. Abstract 4003