5-FU + LV + Mitomycin + Dipyridamole

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Indication

Chemotherapy for locally advanced unresectable cancer

  • 5-FU 200 mg/m2/d civi x 4 weeks q5w
  • Leucovorin 30 mg/m2 iv bolus qw x 4 weeks q5w
  • Mitomycin 10 mg/m2 (max 15 mg) iv bolus q6w x 4 doses
  • Dipyridamole 75 mg po tid during FU administration
  • Surgical resection if tumor becomes resectable

References

Isacoff WH et al. Phase II trial of infusional fluorouracil, leucovorin, mitomycin, and dipyridamole in locally advanced unresectable pancreatic adenocarcinoma: SWOG S9700. J Clin Oncol 2007; 25:1665