5-FU + LV + RT

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Indication

Adjuvant chemoradiation for stage IB, II, III and non-metastatic IV cancer

  • Leucovorin 20 mg/m2/d iv d1-5

One month later

  • 5-FU 400 mg/m2/d d1-4 and last 3 days of RT
  • Leucovorin 20 mg/m2/d iv d1-4 and last 3 days of RT
  • Radiotherapy 1.8 Gy/d to 45 Gy

One month after completion of RT

  • 5-FU 425 mg/m2/d iv d1-5 q4w x 2 cycles
  • Leucovorin 20 mg/m2/d iv d1-5 q4w x 2 cycles

References

Macdonald, JS et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001; 345:725