5-FU MitomycinC Radiation Therapy EORTC Regimen

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 * 5-Flurouracil: 750mg/m2/day IV continuous infusion on days 1-5 and 29-33
 * Mitomycin-C: 15mg/m2 IV on day 1
 * Radiation therapy: 180 cGy/day over 5 week period (total dose 4,500 cGy)

Chemotherapy is given concurrently with radiation therapy. If partial or complete response, a boost of 1,500-2,000 cGy is given


Bartelink H, et al. Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the EORTC Radiotherapy and Gastrointestinal Cooperative Groups. //J Clin Oncol// 1997: 15:2040-2049