5-FU MitomycinC Radiation Therapy Wayne State Regimen

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 * 5-Fluorouracil 1000mg/m2/day continuous infusion on days 1-4 and 29-32
 * Mitomycin-C 15mg/m2 IV on day 1
 * Radiation therapy: 200cGy/day on days 1-5, 8-12, and 5-19 (total dose 3,000 cGy)

Chemotherapy is given concurrently with radiation therapy


Nigro ND, et al. Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal. //Cancer//. 1983;51:1826-1829