AI

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Regimen

AI regimen 1

  • Doxorubicin (Adriamycin) 50 mg/m2 iv bolus d1
  • Ifosfamide 5 g/m2 iv over 24 hrs d1
  • Mesna 600 mg/m2 iv bolus before ifosfamide
  • Mesna 2.5 g/m2 mixed with ifosfamide iv over 24 hrs
  • Mesna 1.25 g/m2 iv over 12 hrs after ifosfamide
  • Q3w

References

Le Cesne, A et al. Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: a trial of the european organization for research and treatment of cancer/soft tissue and bone sarcoma group. J Clin Oncol 2000; 18:2676

AI regimen 2

  • Doxorubicin (Adriamycin) 60 mg/m2 civi over 72 hrs d1
  • Ifosfamide 1.5 g/m2/d iv over 2 hrs d1-4
  • Mesna 225 mg/m2 iv over 1 h before ifosfamide, 4 hrs and 8 hrs after ifosfamide
  • Filgrastim (Neupogen) 5 mcg/kg sc qd x 10 days starting on day 5
  • Q3w

References

Worden, FP et al. Randomized phase II evaluation of 6 g/m2 of ifosfamide plus doxorubicin and granulocyte colony-stimulating factor (G-CSF) compared with 12 g/m2 of ifosfamide plus doxorubicin and G-CSF in the treatment of poor-prognosis soft tissue sarcoma. J Clin Oncol 2005; 23:105