ATRA plus As203

From OncoWiki
Jump to: navigation, search

Regimen

  • All trans retinoic avid (ATRA) 45 mg/m2 po qd in 2 divided doses d1 till CR
  • Arsenic Trioxide (As2O3) 0.15 mg/kg/d iv over 1 h d10 till CR

If WBC > 10 x 109/L, add

  • Gemtuzumab (Mylotarg) 9 mg/m2 iv d1 and/or
  • Idarubicin 12 mg/m2/d iv d1-4

Once CR obtained, change to

  • All trans retinoic avid (ATRA) 45 mg/m2 po qd in 2 divided doses 2 wks on and 2 wks off x 28 wks
  • Arsenic Trioxide (As2O3) 0.15 mg/kg/d iv d1-5 qw 4 wks on and 4 wks off x 28 wks


References

Tsimberidou AM et al. Clinical outcomes and rates of molecular remission with all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) combination therapy in newly diagnosed acute promyelocytic leukemia (APL). 2006 ASCO annual meeting. Abstract 6503

Estey E et al. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. Blood 2006; 107:3469