Arsenic Trioxide for relapsed APML

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Regimen

Induction Therapy

ATO was administered at a dose of 0.15 mg/kg given daily until bone marrow remission was observed (defined as the complete disappearance of all leukemic myeloblasts and promyelocytes and 5% overall myeloblasts by morphologic evaluation of the marrow), up to a cumulative maximum of 60 doses (Median 35 doses)

The prescribed daily dose was diluted in 5% dextrose and administered intravenously for 2 hours

Consolidation Treatment

Additional course of ATO as consolidation beginning 3 to 4 weeks after completion of their induction therapy
The dose for the consolidation course was the same as that administered during induction (0.15 mg/kg iv qd)
Treatment was given either daily, weekdays only, or on some combination thereof until a cumulative total of 25 doses were administered

References

Soignet et al, United States Multicenter Study of Arsenic Trioxide in Relapsed Acute Promyelocytic Leukemia Journal of Clinical Oncology, Vol 19, Issue 18 (September), 2001: 3852-3860

Chao Niu et al, Studies on Treatment of Acute Promyelocytic Leukemia With Arsenic Trioxide: Remission Induction, Follow-Up, and Molecular Monitoring in 11 Newly Diagnosed and 47 Relapsed Acute Promyelocytic Leukemia Patients Blood, Vol. 94 No. 10 (November 15), 1999: pp. 3315-3324