BFM B-Cell
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Regimen
Prephase
Cyclophosphamide 200mg/m2 IVI 1 hr days 1-5 Prednisolone 60mg/m2 PO days 1-5
Block A
Ifosfamide 800mg/m2 IVI 1 hr days 1-5 Vincristine 1.4mg/m2 IVB day 1 Methotrexate 1gm/m2 iv infusion over 24 hours day 1 Folinic acid rescue must start exactly 18 hours upon completion of methotrexate. Folinic acid (Leucovorin) 25mg/m2 oral 6 hourly x 8 doses, then 15 mg/m2 6 hourly x 8 doses. Intrathecal methotrexate 12.5mg and Ara C 40mg day 1,5 VM26 100mg/m2 iv infusion over 1 hour day 4,5 Ara C 150mg/m2 iv infusion over 1 hour bd day 4,5 Dexamethasone 10mg/m2 PO days 1-5
Block B
Cyclophosphamide 200 mg/m2 iv infusion over 1 hour days 1-5 Vincristine 1.4mg/m2 IVB day 1 Methotrexate 1gm/m2 iv infusion over 24 hours day 1 Folinic acid rescue must start exactly 18 hours upon completion of methotrexate. Folinic acid (Leucovorin) 25mg/m2 oral 6 hourly x 8 doses, then 15 mg/m2 6 hourly x 8 doses. Intrathecal methotrexate 12.5mg and Ara C 40mg day 1,5 Adriamycin 25 mg/m2 IVB days 4,5 Dexamethasone 10mg/m2 PO days 1-5
Cycles alternate between Block A and Block B q 21-28 days x 6 cycles