CALGB 9111
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Regimen
Cycle 1 (4 wks)
Cyclophosphamide (Cytoxan) 1200 mg/m2 iv d1 Doxorubicin (Adriamycin) 45 mg/m2/d iv d1, 2, 3 Vincristine 2 mg iv d1, 8, 15, 22 Prednisone 60 mg/m2 po or iv qd d1-21 L-Asparaginase 6000 IU/m2 sc or im d5, 8, 11, 15, 18, 22 Reduce doses if patients older than 60: Cyclophosphamide (Cytoxan) 800 mg/m2 iv d1 Doxorubicin (Adriamycin) 30 mg/m2/d iv d1, 2, 3 Prednisone 60 mg/m2 po qd d1-7 Filgrastim (Neupogen) 5 mcg/kg sc qd d4 till ANC > 1000/uL
Cycle 2 (4 wks,repeat once)
Cyclophosphamide (Cytoxan) 1000 mg/m2 iv d1 6-Mercaptopurine (6-MP) 60 mg/m2/d po d1-14 Cytarabine (Ara-C) 75 mg/m2/d sc d1-4 and 8-11 Vincristine 2 mg iv d15, 22 L-Asparaginase 6000 IU/m2 sc or im d15, 18, 22, 25 Intrathecal MTX 15 mg d1 Filgrastim (Neupogen) 5 mcg/kg sc qd d2 till ANC > 5000/uL
Cycle 3 (12 wks)
6-Mercaptopurine (6-MP) 60 mg/m2/d po d1-70 Methotrexate(MTX) 20 mg/m2 po d36, 43, 50, 57, 64 Intrathecal MTX 15 mg d1, 8, 15, 22, 29 Brain radiation 24 Gy d1-12
Cycle 4 (8 wks)
Doxorubicin (Adriamycin) 30 mg/m2/d iv d1, 8, 15 Vincristine 2 mg iv d1, 8, 15 Dexamethasone (Decadron) 10 mg/m2/d po d1-14 Cyclophosphamide (Cytoxan) 1000 mg/m2 iv d29 6-Thioguanine 60 mg/m2/d po d29-42 Cytarabine (Ara-C) 75 mg/m2/d sc d29-32 and 36-39
Cycle 5 (16 months)
Vincristine 2 mg iv d1 qm Prednisone 60 mg/m2/d d1-5 qm Methotrexate (MTX) 20 mg/m2/d po d1, 8, 15, 22 6-Mercaptopurine (6-MP) 60 mg/m2/d po d1-28