CALGB 9111

From OncoWiki

Regimen

Cycle 1 (4 wks)

Cyclophosphamide (Cytoxan) 1200 mg/m2 iv d1
Doxorubicin (Adriamycin) 45 mg/m2/d iv d1, 2, 3
Vincristine 2 mg iv d1, 8, 15, 22
Prednisone 60 mg/m2 po or iv qd d1-21
L-Asparaginase 6000 IU/m2 sc or im d5, 8, 11, 15, 18, 22
Reduce doses if patients older than 60:
Cyclophosphamide (Cytoxan) 800 mg/m2 iv d1
Doxorubicin (Adriamycin) 30 mg/m2/d iv d1, 2, 3
Prednisone 60 mg/m2 po qd d1-7
Filgrastim (Neupogen) 5 mcg/kg sc qd d4 till ANC > 1000/uL

Cycle 2 (4 wks,repeat once)

Cyclophosphamide (Cytoxan) 1000 mg/m2 iv d1
6-Mercaptopurine (6-MP) 60 mg/m2/d po d1-14
Cytarabine (Ara-C) 75 mg/m2/d sc d1-4 and 8-11
Vincristine 2 mg iv d15, 22
L-Asparaginase 6000 IU/m2 sc or im d15, 18, 22, 25
Intrathecal MTX 15 mg d1
Filgrastim (Neupogen) 5 mcg/kg sc qd d2 till ANC > 5000/uL

Cycle 3 (12 wks)

6-Mercaptopurine (6-MP) 60 mg/m2/d po d1-70
Methotrexate(MTX) 20 mg/m2 po d36, 43, 50, 57, 64
Intrathecal MTX 15 mg d1, 8, 15, 22, 29
Brain radiation 24 Gy d1-12

Cycle 4 (8 wks)

Doxorubicin (Adriamycin) 30 mg/m2/d iv d1, 8, 15
Vincristine 2 mg iv d1, 8, 15
Dexamethasone (Decadron) 10 mg/m2/d po d1-14
Cyclophosphamide (Cytoxan) 1000 mg/m2 iv d29
6-Thioguanine 60 mg/m2/d po d29-42
Cytarabine (Ara-C) 75 mg/m2/d sc d29-32 and 36-39

Cycle 5 (16 months)

Vincristine 2 mg iv d1 qm
Prednisone 60 mg/m2/d d1-5 qm
Methotrexate (MTX) 20 mg/m2/d po d1, 8, 15, 22
6-Mercaptopurine (6-MP) 60 mg/m2/d po d1-28

References

Larson RA et al. A randomized controlled trial of filgramstim during remission induction and consolidation chemotherapy for adults with acute lymphoblastic lymphoma: CALGB study 9111. Blood 1998; 92:1556