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Cyclophosphamide 750 mg/m2 IV on day 1
Mitoxantrone 10 mg/m2 IV on day 1
Vincristine 1.4 mg/m2 IV on day 1 (max 2 mg)
Prednisone 50 mg/m2 PO on days 1-5

Repeat cycle every 21 days


Sonneveld P, et al. Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkin's lymphoma using CHOP versus CNOP J Clin Oncol. 1995 Oct;13(10):2530-9.