Carboplatin + Paclitaxel

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Indication

Bladder Cancer

Chemotherapy for metastatic bladder cancer

  • Carboplatin AUC 6 iv d1
  • Paclitaxel (Taxol) 225 mg/m2 iv over 3 hrs d1
  • Q3w x 6 cycles

References

Vaughn DJ et al. Phase II study of paclitaxel plus carboplatin in patients with advanced carcinoma of the urothelium and renal dysfunction (E2896). A trial of Eastern Oncology Group. Cancer 2002; 95:1022

Endometrial Cancer

Chemotherapy for stage IVB (metastatic) cancer

  • Carboplatin AUC 5-7 iv d1
  • Paclitaxel (Taxol) 175 mg/m2 iv d1
  • Q4w

References

Hoskins, PJ et al. Paclitaxel and carboplatin, alone or with irradiation, in advanced or recurrent endometrial cancer: a phase II study. J Clin Oncol 2001; 19:4048

Ovarian Epithelial Cancer

Adjuvant chemotherapy

  • Carboplatin AUC 5-7.5 iv over 1 hr d1
  • Paclitaxel (Taxol) 175 mg/m2 iv over 3 hrs d1
  • Q3w x 6 cycles

References

Ozols, RF et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol 2003; 21:3194

Du Bois, A et al. A randomized clinical trial of cisplatin/paclitaxel versus carboplatin/paclitaxel as first-line treatment of ovarian cancer. J Natl Cancer Inst 2003; 95:1320

Neijt, JP et al. Exploratory phase III study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancer. J Clin Oncol 2000; 18:3084

Chemotherapy for recurrent or metastatic cancer

  • Carboplatin AUC 5-6 iv d1
  • Paclitaxel (Taxol) 175 mg/m2 iv over 3 hrs d1
  • Q3w

References

The ICON and AGO collaborators. Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet 2003; 361:2099

Lung Cancer Non Small Cell

Adjuvant chemotherapy for stage IB, II and IIIA cancer

  • Carboplatin AUC 6 iv d1
  • Paclitaxel (Taxol) 200 mg/m2 iv d1
  • Q3w x 4 cycles

References

Strauss GM et al. Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection of stage IB non-small cell lung cancer (NSCLC): report of Cancer and Leukemia Group B (CALGB) protocol 9633 (abstract). 2004 ASCO annual meeting. Abstract 7019

Chemotherapy for stage IV (metastatic) cancer

  • Carboplatin AUC 5-6 iv day 1
  • Paclitaxel (Taxol) 175-225 mg/m2 iv day 1
  • Q3w

References

Schiller JH et al. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Eng J Med 2002; 346:92