Cisplatin + Etoposide or Vinorelbine or Vinblastine or Vindesine

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Indication

Adjuvant chemotherapy for stage IB, II and IIIA cancer

  • Cisplatin 50 mg/m2 iv d1 and 8 q4w x 4 cycles, or
  • Cisplatin 80 mg/m2 iv d1 q3w x 4 cycles, or
  • Cisplatin 100 mg/m2 iv d1 q4w x 3-4 cycles, or
  • Cisplatin 120 mg/m2 iv d1 q4w x 3 cycles

plus

  • Etoposide 100 mg/m2/d iv d1-3 q3-4w till completion of cisplatin, or
  • Vinorelbine 25-30 mg/m2 iv qw till completion of cisplatin, or
  • Vinblastine 4 mg/m2 iv qw d1-29, then q2w after d43 till completion of cisplatin, or
  • Vindesine 3 mg/m2 iv qw d1-29, then q2w after d43 till completion of cisplatin

References

Pepe C et al. Adjuvant vinorelbine and cisplatin in elderly patients: National Cancer Institute of Canada and Intergroup Study JBR.10. J Clin Oncol 2007; 25:1553

Winton T et al. Vinorelbine plus cisplatin vs. observation in resected non-small cell lung cancer. N Engl J Med 2005; 352:2589

Arriagada R et al. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer. N Eng J Med 2004; 350:351