Clofarabine, cyclophosphamide and etoposide

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Clofarabine 40 mg/m2 over 2 h IVI day 1-5
Cyclophosphamide 400 mg/m2 over 1 h day 1-5
Etoposide 150 mg/m2 over 2 hr day 1-5


Prophylactic steroids were given to prevent cytokine release syndrome in patients with more than 30x 10^9 blast cells/l in peripheral blood at time of treatment


Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia. Locatelli et al. Br J Haematol. 2009 Nov;147(3):371-8. Epub 2009 Aug 29.Fulltext