Docetaxel

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Drug information

Regimen

Biliary Tract Cancer

  • Docetaxel (Taxotere) 100 mg/m2 iv
  • Q3w

References

Papakostas, P et al. First-line chemotherapy with docetaxel for unresectable or metastatic carcinoma of the biliary tract. A multicentre phase II study. Eur J Cancer 2001; 37:1833

Kaposi's Sarcoma

  • Docetaxel (Taxotere) 25 mg/m2 iv qw x 8 wks, then qow

References

Lim, ST . Weekly docetaxel is safe and effective in the treatment of advanced-stage acquired immunodeficiency syndrome-related Kaposi sarcoma. Cancer 2005; 103:417

Indication

Lung Cancer Non Small Cell

Chemotherapy for stage IV (metastatic) cancer

Regimen 1

  • Docetaxel (Taxotere) 75 mg/m2 iv q3w
References

Fidias P et al. Phase III study of immediate versus delayed docetaxel after induction therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer: updated report with survival. 2007 ASCO annual meeting. LBA7516

Chen YM et al. A randomized trial of different decetaxel schedules in non-small cell lung cancer patients who failed previous platinum-based chemotherapy. Chest 2006; 129:1031

Regimen 2

  • Docetaxel (Taxotere) 36 mg/m2 iv qw x 6wks every 8 wks
References

Schuette W et al. Phase III study of second-line chemotherapy for advanced non-small-cell lung cancer with weekly compared with 3-weekly docetaxel. J Clin Oncol 2005; 23:8389

Hainsworth JD et al. Weekly docetaxel in the treatment of elderly patients with advanced non-small cell lung cancer. Cancer 2000; 89:328