EPOCH-DA: Difference between revisions
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=== Supportive medications === | === Supportive medications === | ||
Filgrastim (Neupogen) 300 mcg sc once per day, starting on day 6 and continuing until ANC > 5,000/uL past nadir | Filgrastim (Neupogen) 300 mcg sc once per day, starting on day 6 and continuing until ANC > 5,000/uL past nadir<br/> | ||
Trimethoprim/Sulfamethoxazole (Bactrim DS) 160/800 mg (or equivalent if allergic) PO once per day on 3 days per week | Trimethoprim/Sulfamethoxazole (Bactrim DS) 160/800 mg (or equivalent if allergic) PO once per day on 3 days per week | ||
Revision as of 07:16, 29 August 2013
Regimen
R-EPOCH-DA: Dose Adjusted EPOCH Regimen, Dunleavy, et al. 2013
Rituximab 375 mg/m2 IV over 3 hours once on day 1 Etoposide 50 mg/m2/day IV continuous infusion over 96 hours on days 1 to 4 (total dose per cycle: 200 mg/m2) Prednisolone 60 mg/m2 PO BID on days 1 to 5 Vincristine 0.4 mg/m2/day IV continuous infusion over 96 hours on days 1 to 4 (total dose per cycle: 1.6 mg/m2) Doxorubicin 10 mg/m2/day IV continuous infusion over 96 hours on days 1 to 4 (total dose per cycle: 40 mg/m2) Cyclophosphamide 750 mg/m2 IV over 2 hours once on day 5
21-day cycles x 6 to 8 cycles
Supportive medications
Filgrastim (Neupogen) 300 mcg sc once per day, starting on day 6 and continuing until ANC > 5,000/uL past nadir
Trimethoprim/Sulfamethoxazole (Bactrim DS) 160/800 mg (or equivalent if allergic) PO once per day on 3 days per week
