EPOCH-DA

Regimen

R-EPOCH-DA: Dose Adjusted EPOCH Regimen, Dunleavy, et al. 2013

Rituximab 375 mg/m2 IV over 3 hours once on day 1
Etoposide 50 mg/m2/day IV continuous infusion over 96 hours on days 1 to 4 (total dose per cycle: 200 mg/m2)
Prednisolone 60 mg/m2 PO BID on days 1 to 5
Vincristine  0.4 mg/m2/day IV continuous infusion over 96 hours on days 1 to 4 (total dose per cycle: 1.6 mg/m2)
Doxorubicin 10 mg/m2/day IV continuous infusion over 96 hours on days 1 to 4 (total dose per cycle: 40 mg/m2)
Cyclophosphamide 750 mg/m2 IV over 2 hours once on day 5