Ewing’s sarcoma and primitive neuroectodermal tumor of bone

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Regimen

  • Cyclophosphamide (Cytoxan) 1200 mg/m2 iv d1, followed by mesna
  • Doxorubicin (Adriamycin) 75 mg/m2 iv bolus d1, change to dactinomycin 1.25 mg/m2 iv d1 when total doxorubicin reaches 375 mg/m2
  • Vincristine 2 mg iv d1

Alternating with

  • Ifosfamide 1.8 g/m2/d iv d1-5, given with mesna
  • Etoposide (VP-16) 100 mg/m2/d iv d1-5
  • Q3w x 17 cycles

References

Holcombe E et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348:694