FLOX

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Indication

Adjuvant chemotherapy

  • 5-FU 500 mg/m2 iv bolus 1 hr after start of leucovorin qw x 6 weeks every 8 weeks for 3 cycles
  • Leucovorin 500 mg/m2 iv over 2 hrs qw x 6 weeks every 8 weeks for 3 cycles
  • Oxaliplatin 85 mg/m2 iv over 2 hrs before 5-FU and Leucovorin week 1, 3, 5 of each 8-week cycle for 3 cycles

References

Kuebler JP et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 2007; 25:2198