FOLFOX6

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Indication

Adjuvant chemotherapy

FOLFOX6

  • Leucovorin 400 mg/m2 iv over 2 hrs before 5-FU d1
  • 5-FU 400 mg/m2 iv bolus d1 followed by 2400 mg/m2 iv over 46 hrs
  • Oxaliplatin 100 mg/m2 iv d1
  • Q2w x 12 cycles

Modified FOLFOX6

  • Leucovorin 400 mg/m2 iv over 2 hrs before 5-FU d1
  • 5-FU 400 mg/m2 iv bolus d1 followed by 2400 mg/m2 iv over 46 hrs
  • Oxaliplatin 85 mg/m2 iv d1
  • Q2w x 12 cycles

References

Tournigand, C et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study. J Clin Oncol 2004; 22:229