Difference between revisions of "High dose Methotrexate"

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Latest revision as of 02:18, 7 February 2012

Drug Information

  • Rheumatrex and Trexall are trade names for Methotrexate. Methotrexate is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as an "antimetabolite."
  • Methotrexate Use and Side Effects

Indication

Primary CNS Lymphoma

Regimen

Methotrexate (MTX) 8 g/m2 iv over 4 hrs q2w till CR or up to 8 cycles, followed by 8 g/m2 iv qm x 11 months

References

Batchelor, T et al. Treatment of primary CNS lymphoma with methotrexate and deferred radiotherapy: A report of NABTT 96-07. J Clin Oncol 2003; 21:1044