Ifosfamide + Paclitaxel

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Indication

Chemotherapy for stage IVB (metastatic) carcinosarcoma

  • Ifosfamide 1.6 g/m2/d (1.2 g/m2/d if patients received prior radiation) iv d1-3
  • Paclitaxel (Taxol) 135 mg/m2 iv over 3 hrs d1
  • Mesna 2 g iv over 12 hrs beginning 15 min before ifosfamide
  • Filgrastim (Neupogen) 5 mcg/kg sc d4 till ANC > 2000
  • Q3w x 8 cycles

References

Homesley HD et al. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group study. J Clin Oncol 2007; 25:526