MACOP-B

From OncoWiki

Regimen

Methotrexate 400 mg/m2 IV on weeks 2,6 and 10
Leucovorin 15 mg/m2 PO every 6 hours for 6 doses, beginning 24 hours after methotrexate
Doxorubicin 50 mg/m2 IV on weeks 1,3,5,7,9 and 11
Cyclophosphamide 350 mg/m2 IV on weeks 1,3,5,7,9 and 11
Vincristine 1.4 mg/m2 IV on weeks 2,4,6,8,10 and 12
Prednisone 75 mg/day PO for 12 weeks with taper over the last 2 weeks
Bleomycin 10 u/m2 IV on weeks 4,8,12
Bactrim DS 1 tablet PO bd
Ketoconazole 200 mg/day PO

References

Klimo P et al. MACOP-B chemotherapy for the treatment of diffuse large-cell lymphoma Ann Intern Med 1985;102:596-602