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Multiple Myeloma

Melphalan + Prednisone + Thalidomide regimen 1

Melphalan (Alkeran) 0.25 mg/kg/d po d1-4 q6w x 12 cycles
Prednisone 2 mg/kg/d po d1-4 q6w x 12 cycles
Thalidomide (Thalomid) 100-400 mg po qd


Facon T et al. Superiority of melphalan-prednisone ( MP) + thalidomide (Thal) over MP and autologous stem cell transplantation in the treatment of newly diagnosed elderly patients with multiple myeloma. 2006 ASCO annual meeting. Abstract 1

Melphalan + Prednisone + Thalidomide regimen 2

Melphalan (Alkeran) 4 mg/m2/d po d1-7 qm x 6 cycles
Prednisone 40 mg/m2/d po d1-7 qm x 6 cycles
Thalidomide (Thalomid) 100 mg po qd till disease progression


Palumbo A et al. Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: a randomized controlled trial. Lancet 2006; 367:825