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Salvage regimen for relapsed/refractory Hodgkin Lymphoma/NHL


Mitoxantrone iv 10 mg/m2 per day on Day 1
Carboplatin iv 100 mg/m2 per day on Days 1-4
Cytosine arabinoside iv 2 g/m2 per day on Day 5
Methylprednisolone iv 500 mg/m2 per day on Days 1-5

Repeat every 28 days

If response after 2-3 cycles, proceed to autologous transplantation

Stem Cell Collection

To collect PBSCs for autologous transplantation, during the second or third course of MiCMA, recombinant human granulocyte-colony-stimulating factor (lenograstim) at a fixed dose of 263 g per day was added on Day + 8 until the patient completed the leukapheretic procedure.

Leukapheresis (LCP) was initiated when the peripheral leukocyte count was > 1.0 × 109/L and there were > 20/ L CD34-positive cells in the peripheral blood. LCP was continued daily until a minimum harvest of 2 × 106 CD34-positive cells/kg was obtained


E. Ortu La Barbera et al, MiCMA: An alternative treatment for refractory or recurrent Hodgkin's disease. Universita' Cattolica Sacro Cuore Roma, Italia. Annals of Oncology, 2000; Volume 11, Number 7