R-MCP

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Regimen

Rituximab 375 mg/m2 IV Day 1
Mitoxantrone 8 mg/m2 IV Days 3-4
Chlorambucil 3 x 3 mg/m2 PO Days 3-7
Prednisolone 25 mg/m2 PO Days 3-7
Repeat cycle every 28 days for 6 cycles

References

Herold M et al. Randomized phase III study for the treatment of advanced indolent non-Hodgkin s lymphomas (NHL) and mantle cell lymphoma: chemotherapy versus chemotherapy plus rituximab. Ann Hematol 2003; 82:77