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Induction phase

Chlorambucil 6 mg/m2 daily PO for 6 weeks
Rituximab 375 mg/m2 weekly IV for 4 weeks

Responding patient to receive consolidation phase 8 weeks from day of commencement

Consolidation phase

Chlorambucil 6 mg/m2 daily PO for 2 weeks every 4 weeks for 4 cycles
Rituximab 375 mg/m2 IV once a month for 4 months


Martinelli G et al. Chlorambucil in combination with induction and maintenance rituximab is feasible and active in indolent non-Hodgkin’s lymphoma. Br J Haematol 2003; 123:271