RICE

Regimen

Cycle 1

Rituximab 375 mg/m2/day IV				day -2
Rituximab 375 mg/m2/day IV				day 1
Etoposide 100 mg/m2/day IV				days 3-5
Carboplatin 5 x (25 + Cr clearance), capped at 800 mg, IV day 4 
Ifosfamide 5 g/m2 (mixed with equal mesna) IV over 24 h	day 4
G-CSF 5 ug/kg/day SC					days 7-14

Subsequent cycles

Rituximab 375 mg/m2/day IV				day 1
Etoposide 100 mg/m2/day IV				days 3-5
Carboplatin 5 x (25 + Cr clearance), capped at 800 mg, IV day 4 
Ifosfamide 5 g/m2 (mixed with equal mesna) IV over 24 h	day 4
G-CSF 5 ug/kg/day SC					days 7-14

Rituximab should be infused in the standard fashion with premedications
If for stem cell mobilization, G-CSF used at 10 ug/kg/day till harvesting

Repeat cycle every 14 days

References

Kewalramani T et al. Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma. Blood. 2004 May 15;103(10):3684-8