RTOG study 93-10

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Regimen

Methotrexate 2500 mg/m2 iv(2-3 h inf) day 1, every other week x 5 (week 1,3,5,7,9)
Folinic acid 20mg p.o. Every 6 h for 12 doses (week 1,3,5,7,9)
Vincristine 1.4 mg/m2 (max 2.8mg) iv day 1, every other week x 5 (wk 1,3,5,7,9)
Procarbazine 100 mg/m2 p.o. Days 1-7 (wk 1,5,9)
Dexamethasone 16->2 mg* p.o. Days 1-7 (wk 1-6)
Methotrexate 12 mg IT day 1 (wk 2,4,6,8,10)
Folinic acid 10 mg bidp.o. For 8 doses (wk 2,4,6,8,10)

  • 16 mg/d for the first week, decreasing to 12,8,6,4 and 2 mg/d over the next 5 weeks

Followed by whole brain radiotherapy (45 Gy in 1.8 Gy fractions wk 11-15)

Cytarabine 3000 mg/m2 iv (3 hr inf) 2 doses separated by 24 hrs (wk 16+19)

References

DeAngelis et al. Combination chemotherapy and radiotherapy for primary central nervous system lymphoma: Radiation Therapy Oncology Group Study 93-10. J Clin Oncol. 20(2002):4643-4648