Thal/Dex

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Multiple Myeloma

Thalidomide ((Thalomid) 100-200 mg po qd
Dexamethasone (Decadron) 40 mg po qd d1-4, 9-12, 17-20 for odd cycles and d1-4 only for even cycles q4w

Thal-Dex was planned to be administered for 4 months in an attempt to reduce tumor cell mass before collection of PBSCs and subsequent autologous transplantation.
Thalidomide was given orally at the starting dose of 100 mg/d for 14 days and then increased to the dose of 200 mg/d.
Pulsed dexamethasone combined with thalidomide was administered at the dose of 40 mg/d on days 1 to 4, 9 to 12, and 17 to 20 (odd cycles) and 40 mg/d for 4 days on even cycles, repeated monthly.
Patients who proceeded to PBSC collection received high-dose cyclophosphamide (HD-CTX; 7 g/m2) and granulocyte-colony stimulating factor (G-CSF; 5 µg/kg/d, starting 48 hours after HD-CTX infusion and continuing until completion of PBSC collection).
Thalidomide was discontinued the day before administration of HD-CTX.
Fixed low-dose prophylactic warfarin (1.25 mg/d) for DVT prevention.

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