TrophoblasticTumors, Gestational

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Methotrexate 1 mg/kg (Maximum daily dose = 50 mg) IM or IV push on days 1, 3, 5, 7 every 2 weeks (total dosage/14 day cycle 4 mg/m2 or 200 mg) Leucovotin calcium 0.1 m0g/kg Oral or IM on days 2, 4, 6, 8 beginning 24 hous after methotrexate administration every 2 weeks (total dose/cycle 60 mg)

Begshawe KD et al Br J Obstet Gynecol 1989;96:795-802 Berkowitz RS et al Gynecol Oncol 1986;23:111-118 Wong LC et al Am J Obstet Gynecol 1985;152:59-62