5-FU + Cisplatin + RT

Indication

Neoadjuvant chemoradiation +/- surgery for resectable cancer

• 5-FU 800 mg/m2/d civi d1-5 starting on d1, 22, 43, 64, 92
• Cisplatin 15 mg/m2/d iv over 1 h d1-5 starting on d1, 22, 43, 64, 92
• Radiotherapy 2 Gy/d to 66 Gy over 6.5 wks

References

Bedenne L et al. Chemoradiation followed by surgery compared with chemoradiation alone in squamous cancer of the esophagus: FFCD 9102. J Clin Oncol 2007; 25:1160

Concurrent chemoradiation for locally advanced cancer

• 5-FU 1000 mg/m2/d civi d1-4 of week 1, 5, 8 and 11
• Cisplatin 75 mg/m2 iv d1 of week 1, 5, 8 and 11
• Radiotherapy 50 Gy

References

Herskovic A et al. Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Eng J Med 1992; 326:1593