5-FU + RT

Indication

Adjuvant chemoradiation

• 5-FU 500 mg/m2/d iv bolus d1-3 repeat once after 2 wks
• Concurrent radiotherapy 2 Gy/d to 20 Gy repeat once after 2 wks

References

Neoptolemos, JP et al. A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 2004; 350:1200

Chemoradiation for locally advanced unresectable cancer

• 5-FU 500 mg/m2/d iv bolus d1-3 and 29-31
• Concurrent radiotherapy to 40 Gy
• Beginning on day 71, 5-FU 500 mg/m2 iv bolus qw till disease progression

References

Moertel, CG et al: Therapy of locally unresectable pancreatic carcinoma: a randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil: The Gastrointestinal Tumor Study Group. Cancer 1981; 48:1705