Carboplatin + Pemetrexed

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Indication

Chemotherapy for stage IV (metastatic) cancer

  • Carboplatin AUC 5 iv d1
  • Pemetrexed (Alimta) 500 mg/m2 iv d1
  • Q3w x 4 cycles
  • Start vitamin supplements 1 week before initial dose of pemetrexed. Folic acid 350-1000 mcg/day orally till 21 days after last dose of pemetrexed. Vitamin B12 1000 mcg I.M. every 9 weeks.
  • Dexamethasone 4 mg twice daily the day before, the day of and the day after pemetrexed

References

Gronberg BH et al. Pemetrexed + carboplatin versus gemcitabine + carboplatin in the treatment of stage IIIB/IV non-small cell lung cancer. 2007 ASCO annual meeting. Abstract 7517

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