Chlorambucil

Drug information

Leukeran

• Manufacturer's monograph (GSK PDF)
• Drug info (drugs.com)

Indications

Indolent NHL

• 10 mg po qd

References

Ardeshna, KM et al. Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trial. Lancet 2003; 362:516

Chronic Lymphocytic Leukemia

• 10 mg/m2/d po x 7 days or 40 mg/m2 po

Q4w x 12 cycles

References

• Catovsky D et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukemia (the LRF CLL4 trial): a randomized controlled trial. Lancet 2007; 370:230
• Rai, KR et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000; 343:1750