Cisplatin + Etoposide + RT

Indication

Lung Cancer Non Small Cell

Induction chemoradiation and adjuvant chemotherapy for superior sulcus cancer

Induction chemoradiation

• Cisplatin 50 mg/m2 iv d1, 8, 29 and 36
• Etoposide (VP-16) 50 mg/m2 iv d1-5 and 29-33
• Radiotherapy 1.8 Gy/d over 5 weeks to 45 Gy

Surgical resection 3-5 weeks later

Adjuvant chemotherapy

• Cisplatin 50 mg/m2 iv d1, 8, 29 and 36
• Etoposide (VP-16) 50 mg/m2 iv d1-5 and 29-33

References

Rusch VW et al. Induction chemoradiation and surgical resection for superior sulcus non-small-cell lung cancinomas: long-term results of Southwest Oncology Group Trial 9416 (Intergroup Trial 0160). J Clin Oncol 2007; 25:313

Lung Cancer Small Cell

Limited stage

• Cisplatin 80 mg/m2 iv d1
• Etoposide (VP-16) 80 mg/m2 iv d1-3
• Q3w x 4 cycles
• Radiotherapy 1.8 Gy once daily to 54-61Gy or 1.5 Gy twice daily to 45 Gy

References

Turrisi AT 3rd et al. Twice daily compared with once daily thoracic radiotherapy in limited small cell lung cancer treated concurrently with cisplatin and etoposide. N Eng J Med 1999; 340:265