Cisplatin + Topotecan

Indication

Cervical Cancer

Chemotherapy for stage IVB (metastatic) cancer

• Cisplatin 50 mg/m2 iv d1
• Topotecan (Hycamtin) 0.75 mg/m2/d iv d1-3
• Q3w x 6 cycles

References

Long HJ 3rd et al. Randomized phase III trial of cisplatin with or without topotecan in carcinoma of the uterine cervix: a Gynecologic Oncology Group Study. J Clin Oncol 2005; 23:4626

Lung Cancer Small Cell

Extensive stage

• Topotecan (Hycamtin) 1.7 mg/m2/d po d1-5
• Cisplatin 60 mg/m2 iv d5
• Q3w x 4 cycles

References

Echcrdt JR et al. Open-label, multicenter, randomized, phase III study comparing oral topotecan/cisplatin versus etoposide/cisplatin as treatment for chemotherapy-naive patients with extensive-disease small-cell lung cancer. J Clin Oncol 2006; 24:2044