Ewing’s sarcoma and primitive neuroectodermal tumor of bone

Regimen

• Cyclophosphamide (Cytoxan) 1200 mg/m2 iv d1, followed by mesna
• Doxorubicin (Adriamycin) 75 mg/m2 iv bolus d1, change to dactinomycin 1.25 mg/m2 iv d1 when total doxorubicin reaches 375 mg/m2
• Vincristine 2 mg iv d1

Alternating with

• Ifosfamide 1.8 g/m2/d iv d1-5, given with mesna
• Etoposide (VP-16) 100 mg/m2/d iv d1-5
• Q3w x 17 cycles

References

Holcombe E et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003; 348:694