FCR

Chronic Lymphocytic Leukemia

• Fludarabine 25 mg/m2/d iv d1-3
• Cyclophosphamide (Cytoxan) 250 mg/m2/d iv d1-3
• Rituximab (Rituxan) 375 mg iv d1 cycle 1 and 500 mg/m2 iv d1 cycle 2-6

Q4w x 6 cycles

• Allopurinol 300 mg po qd d1-7 cycle 1
• Sulfamethoxazole-trimethoprim (Bactrim) DS 1 po bid twice a week
• Valacyclovir 500 mg po qd

References

• Keating M et al. Early results of a chemoimmunotherapy regimen of fludarabine, cyclophosphamide, and rituximab as initial therapy for CLL. J Clin Oncol 2005; 22:4079