FLOX

Indication

Adjuvant chemotherapy

• 5-FU 500 mg/m2 iv bolus 1 hr after start of leucovorin qw x 6 weeks every 8 weeks for 3 cycles
• Leucovorin 500 mg/m2 iv over 2 hrs qw x 6 weeks every 8 weeks for 3 cycles
• Oxaliplatin 85 mg/m2 iv over 2 hrs before 5-FU and Leucovorin week 1, 3, 5 of each 8-week cycle for 3 cycles

References

Kuebler JP et al. Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07. J Clin Oncol 2007; 25:2198