FOLFIRI + Bevacizumab

Indication

Chemotherapy for stage IV (metastatic) cancer

• Leucovorin 400 mg/m2 iv over 2 hrs before 5-FU d1
• 5-FU 400 mg/m2 iv bolus d1, and then 2400 mg/m2 iv over 46 hrs
• Irinotecan (Camptosar, CPT-11) 180 mg/m2 iv d1
• Bevacizumab (Avastin) 5 mg/kg iv d1
• Q2w

References

Fuchs C et al. Updated results of BICC-C study comparing first-line irinotecan/fluoropymidine combinations with or without celecoxib in mCRC: updated efficacy data. 2007 ASCO annual meeting. Abstract 4027