FOLFOX4

Indication

Adjuvant chemotherapy

• Leucovorin 200 mg/m2 iv over 2 hrs before 5-FU, d1 and 2
• 5-FU 400 mg/m2 iv bolus and then 600 mg/m2 iv over 22 hrs, d 1 and d2
• Oxaliplatin 85 mg/m2 iv d1
• Q2w x 12 cycles

References

Andre, T et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 2004; 350:2343

Chemotherapy for stage IV (metastatic) cancer

• Leucovorin 200 mg/m2 iv over 2 hrs before 5-FU, d1 and 2
• 5-FU 400 mg/m2 iv bolus and then 600 mg/m2 iv over 22 hrs, d 1 and d2
• Oxaliplatin 85 mg/m2 iv d1
• Q2w

References

Nordlinger B et al. Final results of the EORTC intergroup randomized phase III study 40983 (EPOC) evaluating the benefit of peri-operative FOLFOX4 chemotherapy for patients with potentially resectable colorectal cancer liver metastasis. 2007 ASCO annual meeting. LBA5

Goldberg, RM et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004; 22:23