FOLFOX6

Indication

Adjuvant chemotherapy

FOLFOX6

• Leucovorin 400 mg/m2 iv over 2 hrs before 5-FU d1
• 5-FU 400 mg/m2 iv bolus d1 followed by 2400 mg/m2 iv over 46 hrs
• Oxaliplatin 100 mg/m2 iv d1
• Q2w x 12 cycles

Modified FOLFOX6

• Leucovorin 400 mg/m2 iv over 2 hrs before 5-FU d1
• 5-FU 400 mg/m2 iv bolus d1 followed by 2400 mg/m2 iv over 46 hrs
• Oxaliplatin 85 mg/m2 iv d1
• Q2w x 12 cycles

References

Tournigand, C et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study. J Clin Oncol 2004; 22:229