FP + Surgery +/- FP

Indication

Perioperative chemotherapy for resectable adenocarcinoma of esophagogastric junction and lower esophagus

• 5-FU 800 mg/m2/d civi d1-5
• Cisplatin 100 mg/m2 iv over 1 h d1 or d2
• Q4w x 2-3 cycles
• Surgery 4-6 weeks after chemotherapy

4-6 weeks after surgery, repeat the chemotherapy if response to preoperative chemotherapy or stable disease with pN+:

• 5-FU 800 mg/m2/d civi d1-5
• Cisplatin 100 mg/m2 iv over 1 h d1 or d2
• Q4w x 3-4 cycles

References

Boige V et al. Final results of a randomized trial comparing preoperative 5-fluorouracil (F) / cisplatin (P) to surgery alone in adenocarcinoma of stomach and lower esophagus (ASLE): FNLCC ACCORD07-FFCD 9703 trial. 2007 ASCO annual meeting. Abstract 4510