Fludarabine

Drug information

Prescribing informatino (Bayer,PDF)

Indications

Indolent NHL

• 25 mg/m2 iv qd d1-5 q4w

References

Klasa, RJ et al. Randomized phase III study of fludarabine phosphate versus cyclophosphamide, vincristine, and prednisone in patients with recurrent low-grade non-Hodgkin's lymphoma previously treated with an alkylating agent or alkylator-containing regimen. J Clin Oncol 2002; 20:4649

Chronic Lymphocytic Leukemia

• 25 mg/m2/d iv x 5 days or 40 mg/m2/d po x 5 days

Q4w x 6-12 cycles

References

• D et al. Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukemia (the LRF CLL4 trial): a randomized controlled trial. Lancet 2007; 370:230
• Rai, KR et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Engl J Med 2000; 343:1750