Gemcitabine + Capecitabine

Regimen

Bile Duct Cancer Extrahepatic

• Gemcitabine (Gemzar) 1000 mg/m2 iv d1, 8
• Capecitabine (Xeloda) 650 mg/m2/d po bid d1-14
• Q3w

References

Knox, JJ et al. Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trial. J Clin Oncol 2005; 23:2332

Indication

Pancreatic Cancer

Chemotherapy for stage IV (metastatic) cancer

Regimen 1

• Gemcitabine (Gemzar) 1000 mg/m2 iv over 30 min d1 and 8
• Capecitabine (Xeloda) 650 mg/m2 po bid d1-14
• Q3w

References

Herrmann R et al. Gemcitabine plus capecitabine compared with gemcitabine alone in advanced pancreatic cancer: a randomized, multicenter, phase III trial of the Swiss Group for Clinical Cancer Research and the Central European Cooperative Oncology Group. J Clin Oncol 2007; 25:2212

Regimen 2

• Gemcitabine (Gemzar) 1000 mg/m2 iv qw for 3 wks every 4 wks
• Capecitabine (Xeloda) 1660 mg/m2/d for 3 wks every 4 wks

References

Cunningham D et al. Phase III randomized comparison of gemcitabine (GEM) versus gemcitabine plus capecitabine (GEM-CAP) in patients with advanced pancreatic cancer. ECCO 13-the European Cancer Conference. Abstract PS11