Gemcitabine + Docetaxel

Regimen

Sarcoma

• Gemcitabine (Gemzar) 675-900 mg/m2 iv over 90 min d1, 8
• Docetaxel (Taxotere) 100 mg/m2 iv over 1 h d8
• Filgrastim (Neupogen) 5 mcg/kg sc qd d9-15
• Q3w

References

Maki RG et al. Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcoma. J Clin Oncol 2007; 25:2755

Hensley, ML et al. Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial. J Clin Oncol 2002; 20:2824

Leu, KM et al. Laboratory and clinical evidence of synergistic cytotoxicity of sequential treament with gemcitabine followed by docetaxel in the treatment of sarcoma. J Clin Oncol 2004; 22:1706

Indication

Lung Cancer Non Small Cell

Chemotherapy for stage IV (metastatic) cancer

• Gemcitabine (Gemzar) 1100 mg/m2 iv d 1 and 8
• Docetaxel (Taxotere) 100 mg/m2 iv day 8
• Q3w
• G-CSF support d 9-15

References

Georgoulias V et al. Platinum-based and non-platinum-based chemotherapy in advanced non-small cell lung cancer: a randomized multucenter trial. Lancet 2001; 357:1478