Gemcitabine + Oxaliplatin

Regimen

Bile Duct Cancer Extrahepatic

• Gemcitabine (Gemzar) 1000 mg/m2 iv d1
• Oxaliplatin (Eloxatin) 100 mg/m2 iv d2
• Q2w

References

Andre, T et al. Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. Ann Oncol 2004; 15:1339

Indication

Pancreatic Cancer

Chemotherapy for stage IV (metastatic) cancer

• Gemcitabine (Gemzar) 1000 mg/m2 iv over 100 min d1
• Oxaliplatin (Eloxatin) 100 mg/m2 iv over 2 hrs d2
• Q2w

References

Louvet, C et al. Gemcitabine in combination with oxaliplatin compared with gemcitabine alone in locally advanced or metastatic pancreatic cancer: results of a GERCOR and GISCAD phase III trial. J Clin Oncol 2005; 23:3509

Poplin E et al. Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion [FDR) versus gemcitabine + oxaliplatin (GEMOX) in patients with advanced pancreatic cancer (E6201). 2006 ASCO annual meeting. Abstract LBA4004]