Paclitaxel

Drug information

Taxol

• Monograph (FDA, PDF)
• Taxol prescribing information (Bristol-Myers Squibb)
• Taxol and Taxol Side Effects Information

Indication

Cervical Cancer

Chemotherapy for stage IVB (metastatic) cancer

• Paclitaxel (Taxol) 110-200 mg/m2 iv
• Q3w

References

McGuire, WP et al. Paclitaxel has moderate activity in squamous cervix cancer. A Gynecologic Oncology Group study. J Clin Oncol 1996; 14:792

Curtin, JP et al. Paclitaxel, an active agent in nonsquamous carcinomas of the uterine cervix: a Gynecologic Oncology Group Study. J Clin Oncol 2001; 19:1275

Endometrial Cancer

Chemotherapy for stage IVB (metastatic) cancer

• Paclitaxel (Taxol) 110-200 mg/m2 iv
• Q3w

References

Ball, HG et al. A phase II trial of paclitaxel in patients with advanced or recurrent adenocarcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol 1996; 62:278

Lissoni, A et al. Phase II study of paclitaxel as salvage treatment in advanced endometrial cancer. Ann Oncol 1996; 7:861

Lincoln, S et al. Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 2003; 88:277

Esophageal Cancer

Chemotherapy for stage IV (metastatic) cancer

• Paclitaxel (Taxol) 250 mg/m2 civi over 24 hrs
• Q3w
• Filgrastim (Neupogen) support

References

Ajani, JA et al. Activity of taxol in patients with squamous cell carcinoma and adenocarcinoma of the esophagus. J Natl Cancer Inst 1994; 86:1086

Ovarian Epithelial Cancer

Maintenance chemotherapy

• Paclitaxel (Taxol) 135 mg/m2 iv
• Q4w x 12 cycles

References

Markman, M et al. Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a Southwest Oncology Group and Gynecologic Oncology Group trial. J Clin Oncol 2003; 21:2460

Lung Cancer Non Small Cell

Chemotherapy for stage IV (metastatic) cancer

Regimen 1

• Paclitaxel (Taxol) 200 mg/m2 iv q3w

References

Tester WJ et al. Phase II study of patients with metastatic non-small cell carcinoma of the lung treated with paclitaxel by 3-hour infusion. Cancer 1997; 79:724

Regimen 2

• Paclitaxel (Taxol) 90 mg/m2 iv qw x 6 wks every 8 wks

References

Fidias P et al. A phase II study of weekly paclitaxel in elderly patients with advanced non-small cell lung cancer. Clin Cancer Res 2001; 7:3942

Lung Cancer Small Cell

Extensive stage

• Paclitaxel (Taxol) 80 mg/m2 iv over 1 hour qw x 6 wks every 8 wks

References

Yamamoto N et al. phase II study of weekly paclitaxel for relapsed and refractory small cell lung cancer. Anticancer Res 2006; 26:777

Regimen

Kaposi's Sarcoma

• Paclitaxel (Taxol) 135 mg/m2 iv over 3 hrs
• Q3w

References

Gill PS et al. Paclitaxel is safe and effective in the treatment of advanced AIDS-related Kaposi’s sarcoma. J Clin Oncol 1999; 17:1876